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Home Supplements/Vitamins Anti-toxins Folic Acid (Natural folate form) 60 Tabs 750µg -Solal Technologi
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Folic Acid (Natural folate form) 60 Tabs 750µg -Solal Technologi
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Folic Acid (Natural folate form) 60 Tabs 750µg -Solal Technologi

Price: R103.00

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Folate (vitamin B9) is primarily indicated for folate deficiencies and during pregnancy to prevent foetal spinal deformities. Folate is involved in the metabolism of homocysteine. Low folate levels are associated with increased plasma homocysteine levels. High homocysteine may be a risk factor for certain chronic diseases. Folate deficiency leads to the formation of abnormal red blood cells called megaloblasts. DEPLETIONS The following medicines and substances can cause a folate deficiency. If you take any of these then it is particularly important that you supplement with folate under medical supervision: alcohol, antacids, antibiotics, anti-inflammatories, carbamazepine, diuretics, estrogens, metformin, methotrexate, methylprednisolone, phenobarbital, phenytoin, sulfasalazine, triamterene, trimethoprim and valproic acid.

Product Composition

Each tablet contains the following as active ingredient:
Folate (L-5-methyltetrahydrofolate calcium)                                                750µg

Storage Instructions

Store in a cool dry place below 25°C. Keep, out of the reach of children.

Pharmacological Action
Folate is the natural form of folic acid found in food. Once absorbed folate enters the methylation cycle. In humans, tetrahydrofolate- based enzymes play a major role in intracellular metabolism. Tetrahydrofolate plays an indirect role in the rate-limiting step of DNA synthesis. Abnormalities in this process that occur with folate deficiency can cause megaloblastic anaemia. Folate is also involved in the metabolism of homocysteine. Low folate levels are associated with increased plasma homocysteine levels. Remethylation of homocysteine to methionine requires folic acid and vitamin B12 as cofactors. Folate supplementation has been shown to reduce the risk of neural tube defects in the foetus.

Dosage Directions
Adults and children over 12 years of age: Take 1 tablet daily. Do not exceed this dose unless on the advice of your health care provider. Dosage during, and one month preceding, pregnancy can be increased to 2 tablets daily, on the advice of your health care provider.

Product Warnings
Do not exceed recommended dosages unless on the advice of a health care provider. Do not use this product if you are allergic to any of the ingredients. If you are on any medication or suffering from any medical condition, it is advisable to seek medical advice before starting any new medicine, supplement or remedy. Safety in children has not been established.


Side Effects
Side effects have not been reported in doses below 1000µg per day. Side effects in doses above 5000µg per day may include abdominal cramps, diarrhoea, and rash. Folate should never be given alone or in conjunction with inadequate amounts of Vitamin B12 for the treatment of megaloblastic or pernicious anaemia.


Contraindications
There are no known contraindications.


Product Interactions
Methotrexate: Methotrexate exerts its cytotoxic effect by preventing the conversion of folic acid to the active form needed by cells. There is some evidence that folic acid supplements reduce the efficacy of methotrexate in the treatment of acute lymphoblastic leukaemia and theoretically other cancers. In individuals treated with long-term, low-dose methotrexate for rheumatoid arthritis (RA) or psoriasis, folic acid supplements can reduce the incidence of side effects, without reducing efficacy. Phenobarbital: Folic acid can have a direct convulsant activity in some individuals, reversing the effects of phenobarbital and worsening seizure control. Monitor closely for increased seizure activity. Phenytoin: Folic acid may be a cofactor in phenytoin metabolism. Folic acid doses of 1mg per day or more, can reduce serum levels of phenytoin in some individuals. Folic acid can have direct convulsant activity, reversing the effects of phenytoin and worsening seizure control. Primidone: Folic acid can have a direct convulsant activity in some people, reversing the effects of primidone and worsening seizure control. Monitor closely for increased seizure activity. Pyrimethamine: Folic acid can antagonize the antiparasitic effects of pyrimethamine against Toxoplasmosis and Pneumocystis carinii pneumonia. Folic acid doesn't antagonize the effects of pyrimethamine in the treatment of malaria, because malarial parasites cannot use exogenous folic acid. Use folinic acid as an alternative to folic acid when indicated. Note that pyrimethamine also reduces serum folate levels.


Special Precautions
Pernicious anaemia: Folic acid can mask pernicious anaemia by decreasing megaloblastic anaemia. This can prevent appropriate treatment with vitamin B12 and result in neurological damage. Individuals should not treat undiagnosed anaemia with folic acid. Seizure disorders: Supplemental folic acid may exacerbate seizures in individuals with seizure disorders, particularly in high doses. Cardiovascular disease: Preliminary research indicates folic acid 800µg plus vitamin B6 40mg daily might increase the risk of myocardial infarction in individuals with a history of cardiovascular disease.


Pregnancy & Breastfeeding
Safe for use in pregnancy and breastfeeding at the recommended doses.

 


Availability

Usually ships in:

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Last Updated: Thursday, 25 April 2019 18:07

Customer Feedback

I would like to thank you for the order that I received today from the post office.Allow me to emphasize that, I value the receipt of this order because of the experience I had with a certain company I cannot mention its name but the service they offered me can never be equaled to the one I received from you.I without doubt believed I will get the best quality service from your company and wished I should have known you earlier. I spent twice the money I paid you when purchasing this product from that company. I will recommend you to my colleagues and will forever order from your company.Thank you once again for your effective, efficient and responsive services rendered to me. - M.N.J - Ga-Kgapane - Limpopo

Thank you very much for looking after my order.  I received the package last Monday 14 March.  I was very impressed, only ordered this the week previous. All contents accounted for and in good order.  Will be ordering again from you and will recommend. - S.F. - England

Everything is in order and I appreciate your great service. I will definitely join you on facebook. - K.N. - Bloemfontein

Thank you so much, I have recieved the product and am very happy. Will definitely shop at iHeal again in the future. - N.L.- Kloof

Thank you for all your kind service! If the crème is really good (this is what I heard) then I am sure It won´t be my last order ;-) - D.J. - Germany

Once again thank you very much for your brilliant service!  I will definitely shop with you again soon.- C.I. - Johannesburg

I have received my parcel in good order today.  Thank you for the follow up.  I will surely do business to you again in future.M.N. - Secunda

I picked up my parcel today with everything in order, thanks for the great service! - T.H. - White River

Thank for an excellent service - L.M. - Johannesburg

Wow now that is what I call Customer Service! Thank you kindly for letting me know :) Thank you very muchJ.S. - Northwold

The parcel was received in good order also thanks for the tea samples! Thank you for keeping in touch and for the great service!  - G.B. - Cape Town

I am so happy that I have finally been able to find that specific product! Looking forward to order through you again. - K.B. - Noordwyk

I am very happy with my product and will tell friends and buy from you again. - S.M. -Jefferys Bay 

I have received my package in perfect condition - P.N. - Cape Town

I have received the product in good order and am most satisfied by it and your service, thank you very much. I will certainly be making use of your service in the future. - M.S. -Alexandria

excellent service. Thank you - C.B. Somerset West, Cape Town

Thank you so much for your quick response. U guys provide an excellent service... this is amazing i must say!!!!!! i am looking foward on doing business with you. And thanks once again for referring me to The Busy Woman's Guide To Healthy Weight Loss. S.S - Somewhere in South Africa

Thank you for the wonderful service and i will making use of iHeal again in the future. thanks again :-) B.R. - Eersterust, Pretoria

Thank you so much for the quick response. I am very impressed!! Your Customer Service delivery is outstanding! Normally one has to wait at least a day or three for any response. I am definitely recommending iHeal website to my friends and family. Sonja - Cape Town

Great service!  C.W. Umzumbe

Thank you very much for you good service..!!! P.K. - Welkom

What excellent service! I will definitely be using your service again and recommending it where I can.  C.K. - Claremont, Cape Town

Thank you very much for your brilliant customer service. I will definitely be supporting iHeal in the future again. - S.B. - Hoedspruit

Thank you so much for all your efforts and follow up.  I wish more companies and people were as efficient as you are. - Pat - Gauteng

Thanks very much for following up. I much appreciate the service. - P.C. - Pokolwane

Thank you very much for the excellent service. - M.P. - Knysna

 
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